History Dependence of Microbead Adhesion under Varying Shear Rate

The recruitment of blood-borne leukocytes to the vascular endothelium is a crucial step in the immune response. It is mediated by specific receptorligand interactions [2,32] that allow circulating leukocytes to form bonds with the endothelium under flow conditions. This results in the so-called adhesive rolling of leukocytes along the blood vessel walls prior to targeting sites of inflammation [20,29,31,34].