ABSTRACT
This technique is useful when the plasma clearance of a substance by the liver is investigated. Information about whether the liver is involved in the plasma clearance or not can be obtained with this technique. Samples of blood are obtained through a venous or arterial catheter before and after the hepatic circulation is impaired, which is described below. In the samples obtained before the maneuver, the liver is included in the clearance, and in the samples obtained after the impairment of circulation, the clearance of the substance is from all tissues except the liver.
