TAIL

Acremonium – target-like lesions with central necrosis Rook p.1375, 1998, Sixth Edition African trypanosomiasis AD 131:1178-1182, 1995 Anthrax – central eschar with surrounding vesicles J Clin Inf Dis 19:1009-1014, 1994 Brown recluse spider bite Burkholderia pseudomallei (melioidosis) – disseminated; ecthyma-like lesions Clin Inf Dis 40:988-989, 1053-1054, 2005 Candida – candidal sepsis; disseminated candidiasis Coccidioidomycosis – erythema multiforme as hypersensivity reaction in acute coccidioidomycosis JAAD 46:743-747, 2002 Coxsackie virus – erythema multiforme-like exanthem Tyring p.460, 2002 Cryptococcal panniculitis – erythema with central hyperpigmentation Cutis 74:165-170, 2004 Ecthyma gangrenosum Erysipeloid (Erysipelothrix insidiosa (E. rhusiopathiae)) in neonate – erythema multiforme-like eruption J Clin Inf Dis 24:511, 1997 Fusarium – sepsis Ped Derm 9:62-65, 1992; Fusarium solanae – target-like lesions with central necrosis Rook p.1375, 1998, Sixth Edition; Eur J Clin Microbiol Infect Dis 13:152-161, 1994 Gonococcemia – hemorrhagic pustules with halo of erythema Rook p.2170-2171, 1998, Sixth Edition; AD 107:403-406, 1973 Hepatitis B – erythema multiforme Ghatan p.246, 2002, Second Edition Herpes simplex virus Histoplasmosis J Cutan Pathol 29:215-2002 Insect bites Leprosy – targetoid erythematous plaques Eur J Dermatol 11:65-67, 2001 Lyme disease (Borrelia burgdorferi ) – erythema (chronicum) migrans JAAD 49:363-392, 2003 Meningococcemia Milker’s nodule (pseudocowpox, bovine papular stomatitis virus) – starts as flat red papule on fingers or face, progresses to red-blue tender nodule, which crusts; zone of erythema; may resemble pyogenic granulomas JAAD 44:1-14, 2001; Rook p.1004, 1998, Sixth Edition; AD 111:1307-1311, 1975 Molluscum contagiosum – molluscum dermatitis Acta DV 82:217-218, 2002

Mycobacterium avium-intracellulare JAAD 39:493-495, 1998 Orf – Parapoxvirus (genus); Family Poxviridae Cutis 71:288-290, 2003; JAAD 44:1-14, 2001 Parvovirus B19 infection – erythema multiforme-like J Clin Inf Dis 21:1424-1430, 1995 Psittacosis – erythema multiforme Br Med J 2:1469-1470, 1965 Rickettsial pox Sealpox (parapoxvirus) – gray concentric nodule with superimposed bulla on dorsum of hand BJD 152:791-793, 2005 Spider bites – black widow spider (Latrodectus mactans) – punctum with erythema and edema AD 123:41-43, 1987; brown recluse spider (Loxosceles reclusa) – erythema, edema, central bulla; targetoid lesion with central blue/purple, ischemic halo, outer rim of erythema; at 3-4 days central necrosis, eschar, ulcer, scar South Med J 69:887-891, 1976 Syphilis – secondary – corymbose lesions; erythema multiforme-like lesions BJD 149:658-660, 2003 Tick bite Tick typhus (Boutonneuse fever, Kenya tick typhus, African and Indian tick typhus) (ixodid ticks) – small ulcer at site of tick bite (tache noire) – black necrotic center with red halo; pink morbilliform eruption of forearms, then generalizes, involving face, palms, and soles; may be hemorrhagic; recovery uneventful JAAD 2:359-373, 1980 Tinea corporis, cruris, faciei, bullous tinea Cutis 6:661-668, 1970 Tinea imbricata Toxic shock syndrome – targetoid spotty rashes Acta DV 82:449-452, 2002 Trichosporon beigelii sepsis Tularemia – erythema multiforme JAAD 49:363-392, 2003 Varicella-zoster infection – varicella or herpes zoster; atypical recurrent varicella with vesiculopapular lesions with central necrosis JAAD 48:448-452, 2003 Verruca vulgaris – rosettes after cryotherapy Tyring p.286, 2002 Yaws – primary red papule, ulcerates, crusted; satellite papules; become round ulcers, papillomatous or vegetative friable nodules which bleed easily (raspberry-like) (framboesia); heals with large atrophic scar with white center with dark halo Rook p.1268-1271, 1998, Sixth Edition Zygomycosis – Rhizopus arrhizus; bull’s eye infarct JAAD 51:996-1001, 2004; JAMA 2254:737-738, 1973

Amyloid – purpuric halos surrounding cherry angiomas Cutis 48:141-143, 1991; BJD 112:209-211, 1985 Digital myxoid cyst

Erythema multiforme Medicine 68:133-140, 1989; JAAD 8:763-765, 1983; marginal ring of vesicles (herpes iris of Bateman) Medicine 68:133-140, 1989; JAAD 8:763-765, 1983; id reaction, erythema multiforme-like J Eur Acad Dermatol Venereol 17:699-701, 2003 Interstitial granulomatous dermatitis BJD 152:814-816, 2005 Kikuchi’s disease (histiocytic necrotizing lymphadenitis) – erythema multiforme lesions Ped Derm 18:403-405, 2002 Neutrophilic eccrine hidradenitis Cutis 75:93-97, 2005 Ofuji’s disease (eosinophilic pustular folliculitis) Cutis 58:135-138, 1996 Pyoderma gangrenosum Rook p.2185, 1998, Sixth Edition; bullous pyoderma gangrenosum JAAD 51:996-1001, 2004

Sarcoid – erythema multiforme-like lesions Cutis 33:461-463, 1984 Relapsing idiopathic nodular panniculitis BJD 152:582-583, 2005 Toxic epidermal necrolysis Australas J Dermatol 43:35-38, 2002

Pruritic urticarial papules and plaques of pregnancy – targetoid lesions JAAD 39:933-939, 1998; JAAD 10:473-480, 1984; Clin Exp Dermatol 7:65-73, 1982; JAAD 5:401-405, 1981; JAMA 241:1696-1699, 1979

Atypical nevus Blue nevi – target blue nevi AD 119:919-920, 1983 Cytophagic histiocytic panniculitis – manifestation of hemophagocytic syndrome; red tender nodules; T-cell lymphoma, B-cell lymphoma, histiocytic lymphoma, sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) Rook p.2419, 1998, Sixth Edition; JAAD 4:181-194, 1981; Arch Int Med 140:1460-1463, 1980 Halo lesions (lesions with halos) AD 92:14-35, 1965

Basal cell carcinoma Blue nevus Cafe au lait macules Ped Derm 15:70-71, 1998 Congenital melanocytic nevus Ped Derm 19:73-75, 2002; J Derm Surg Oncol 16:377-380, 1990 Histiocytoma Nevocellular nevus Primary melanoma Metastatic melanoma Neurofibroma AD 112:987-990, 1976 Seborrheic keratosis Involuting flat wart

HTLV-1 leukemia, lymphoma Kaposi’s sarcoma Lymphoma – cutaneous T-cell lymphoma Rook p.2376, 1998, Sixth Edition; CTCL mimicking erythema multiforme JAAD 47:914-918, 2002; nasal T-cell lymphoma Pathology 21:164-168, 1989 Lymphomatoid papulosis Melanocytic nevus Rook p.1722-1723, 1998, Sixth Edition; cockarde nevus Ped Derm 5:250-253, 1988; eclipse nevus – tan center with stellate brown rim BJD 145:1023-1026, 2001; halo nevus (Sutton’s nevus; leukoderma acquisitum centrifugum) AD 92:14-35, 1965; Myerson’s nevus – melanocytic nevus with surrounding dermatitis AD 103:510-512, 1971; due to interferon-α and ribavirin BJD 152:193-194, 2005; atypical nevus JAAD 34:357-361, 1996 Melanoma – primary, metastatic Semin Oncol 2:5-118, 1975 Metastases – lung cancer, plurivisceral carcinoma BJD 148:361, 2003 Nevocentric lesions JAAD 33:842-843, 1995

Erythema multiforme Halo dermatitis Halo nevus JAAD 29:267-268, 1993 Nummular dermatitis (Meyerson’s nevus – halo dermatitis) BJD 118:125-129, 1988 Pityriasis rosea Psoriasis Targetoid halo nevus

Spitz nevus Am J Dermatopathol 17:484-486, 1995; JAAD 27:901-913, 1992

Glucagonoma syndrome – alpha cell tumor in the tail of the pancreas; 50% of cases have metastasized by the time of diagnosis; skin rash, angular stomatitis, cheilosis, beefy red glossitis, blepharitis, conjunctivitis, alopecia, crumbling nails; rarely, associated with MEN I or IIA syndromes Rook p.2728, 1998, Sixth Edition; AD 133:909, 912, 1997; JAAD 12:1032-1039, 1985; Ann Intern Med 91:213-215, 1979 Paraneoplastic pemphigus – targetoid erythema multiforme-like lesions BJD 145:127-131, 2001; Cutis 61:94-96, 1998; NEJM 323:1729-1735, 1990

Hydroa vacciniforme Polymorphic light eruption

Alopecia areata – targetoid hair regrowth AD 134:1042, 1998 Annular lichenoid dermatitis of youth JAAD 49:1029-1036, 2003 Epidermolysis bullosa simplex – Dowling-Meara type AD 122:190-198, 1986 Eruptive pseudoangiomatosis AD 140:757-758, 2004 Erythema annulare centrifugum Erythrokeratoderma en cocardes Ped Derm 19:285-292, 2002 Erythrokeratolysis hiemalis – keratolytic winter erythema (Oudtshoorn disease) – palmoplantar erythema, cyclical and centrifugal peeling of affected sites, targetoid lesions of the hands and feet – seen in South African whites; precipitated by cold weather or fever Ped Derm 19:285-292, 2002; BJD 98:491-495, 1978 Febrile ulceronecrotic Mucha-Habermann disease JAAD 49:1142-1148, 2003 Granuloma annulare Rook p.2300, 1998, Sixth Edition; giant inflammatory targetoid plaques AD 128:979, 982, 1992; AD 105:928, 1972 Nummular dermatitis may surround: JAAD 33:842-843, 1995

Basal cell carcinoma Dermatofibromas Insect bites Keloids Lentigines Nevus – Meyerson’s nevus Squamous cell carcinoma Seborrheic keratosis Stucco keratosis

Pityriasis rosea JAAD 15:159-167, 1986; pityriasis rosea with erythema multiforme-like lesions JAAD 17:135-136, 1987 Psoriasis – Woronoff rings BJD 148:170, 2003 Toxic erythema of newborn

Factitial dermatitis

Behçet’s disease Yonsei Med J 38:380-389, 1997 Erythrokeratoderma variabilis

Kawasaki’s disease – erythema multiforme-like Cutis 72:354-356, 2003; JAAD 39:383-398, 1998; Jpn J Allergol 16:178-222, 1967 Marshall’s syndrome AD 131:1175-1177, 1995 Rowell’s syndrome – lupus erythematosus and erythema multiforme-like syndrome – papules, annular targetoid lesions, vesicles, bullae, necrosis, ulceration, oral ulcers; perniotic lesions JAAD 21:374-377, 1989 Sweet’s syndrome AD 141:881-884, 2005; Textbook of Neonatal Dermatology, p.305, 2001; in chronic granulomatous disease Ped Derm 11:237-240, 1994 Turner’s syndrome – halo nevi JAAD 51:354-358, 2004 Vogt-Koyanagi-Harada syndrome – halo nevi; occurs primarily in Asians, blacks, and darkly pigmented Caucasians; stage 1 – aseptic meningitis; stage 2 – uveitis (iritis, iridocyclitis) and dysacusis (tinnitus, hearing loss); stage 3 – depigmentation of skin (60% of patients), depigmentation of hair (poliosis – eyelashes, eyebrows, scalp, and body hair – 90% of patients), alopecia areata Ann DV 127:282-284, 2000; AD 88:146-149, 1980

Radiation therapy Australas Radiol 40:334-337, 1996 Ricocheted action safety bullet marks Am J Forensic Med Pathol 18:15-20, 1997 S/P treatment with liquid nitrogen

Acute hemorrhagic edema of infancy (Finkelstein’s disease) (Seidlmayer’s purpura) Ped Int 45:697-700, 2003; Cutis 68:127-129, 2001; J Dermatol 28:279-281, 2001; Cutis 61:283-284, 1998; AD 130:1055-1060, 1994 Angiolymphoid hyperplasia with eosinophilia Ped Derm 15:91-96, 1998 Bossed hemangioma with telangiectasia and peripheral pallor AD 134:1145-1150, 1998 Cherry angioma BJD 112:209-211, 1985 Churg-Strauss disease – erythema multiforme-like lesions Rook p.2221, 1998, Sixth Edition Degos’ disease (malignant atrophic papulosis) BJD 100:21-36, 1979; Ann DV 79:410-417, 1954 Hemangioma of pregnancy JAAD 32:282-284, 1995 Hemangioma, traumatized Henoch-Schönlein purpura mimicking erythema multiforme Leukocytoclastic vasculitis; Henoch-Schönlein purpura; urticarial vasculitis AD 134:231-236, 1998; erythema multiforme-like lesions Rook p.2178, 1998, Sixth Edition Non-involuting congenital hemangioma – round to ovoid pink to purple papule or plaque with central or peripheral pallor, coarse telangiectasias JAAD 50:875-882, 2004 Pustular vasculitis – annular pustular plaques with central necrosis Rook p.2167, 1998, Sixth Edition Targetoid hemosiderotic hemangioma – brown to violaceous nodule with ecchymotic halo Cutis 72:51-52, 2003; AD 138:117-122, 2002; AD 136:1571-1572, 2000; J Cutan Pathol 26:279-286, 1999; JAAD 32:282-284, 1995; JAAD 41:215-224, 1999 Wegener’s granulomatosis – erythema multiforme-like lesions