ABSTRACT

Parameter estimates obtained from samples are usually meant to be used to estimate the true population parameters. The sample mean and variance are typical estimators or predictors of the true mean and variance, and are often called “point” estimates. In addition, an interval that is apt to contain the true parameter often accompanies and complements the point estimate. These intervals, known as confidence intervals, can be constructed with a known a priori probability of bracketing the true parameters. Confidence intervals play an important role in the evaluation of drugs and drug products.