ABSTRACT
INTRODUCTION Although major progress has been made in the field of novel drug delivery technologies, oral intake remains the preferred route of drug administration. Oral intake is most convenient for the patient and results in best therapy compliance. Drugs administered orally must exhibit adequate biopharmaceutical properties leading to therapeutic concentrations at the targeted site of action. Early screening of drug candidates, not only for their pharmacological activity, but also for biopharmaceutical and physicochemical properties has become the signature of the contemporary drug discovery paradigm (1).
