ABSTRACT

INTRODUCTION To facilitate development and to ensure the quality of drug products, it is desirable to have in vitro test systems that can be used to forecast their in vivo behavior. Of the quality control tests generally described in pharmacopeias, dissolution tests seem to be the most closely associated with in vivo performance of oral drug products. This is principally because the release/dissolution step is prerequisite to the drug absorption process from many dosage forms administered orally.