ABSTRACT
Globule States of Soluble Proteins ................................................. 369 16.3.3 Collective Dynamics of Protein Hydration Water ......................... 371 16.3.4 Dynamical Transition as a Probe of Protein-Solvent
Dynamical Coupling ...................................................................... 373 16.3.5 Dynamical Transitions in Purple Membrane ................................. 376 16.3.6 Role of Protein-Solvent Hydrogen-Bond Dynamics
in Dynamical Transitions ............................................................... 377 16.4 Concluding Remarks and Outlook ..............................................................380 Acknowledgments .................................................................................................. 382 References .............................................................................................................. 382
Proteins exhibit a broad spectrum of motions over a wide range of length scales, and spanning many decades of time. Under physiological conditions in their native states, proteins undergo localized, fast conformational uctuations (picosecond to nanosecond timescales) around a well-de ned three-dimensional structure. The folding and function of proteins generally involves much slower, large-scale transitions (more than microsecond timescales) between stable conformations. In the energy landscape picture of protein dynamics, protein motions on such disparate time scales are connected [1].
