ABSTRACT
I. Cocaine Kinetics in Humans.................................................................................... 54
II. The Urinary Excretion of Cocaine and Metabolites in Humans: A Kinetic Analysis of Published D ata....................................................................................... 60 A. Literature D ata............................................................................................... 60 B. Kinetic Analysis............................................................................................. 61
References............................................................................................................................... 68
I. COCAINE KINETICS IN HUMANS
Despite its widespread use, there have been few attempts to relate the disposition kinetics of cocaine to the responses that this drug elicits. The euphoric and cardiovascular effects have been reported to decline more rapidly than cocaine leaves the plasma after a single dose.1 Although this phenomenon may or may not indicate tolerance, other observations indicate that cocaine does exhibit acute tolerance development. An intravenous dose of cocaine given after a 96-mg intranasal dose produces a less intense response than the same intravenous dose administered after a placebo dose.2 Such a phenomenon is of considerable pharmacological interest and is of critical importance in interpreting cocaine plasma con centrations.
