ABSTRACT

Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. xiii Contributors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xvii

1. Time-Controlled Drug Delivery Systems . . . . . . . . . . . . . . . . . . . . . . . . 1 Juergen Siepmann and Florence Siepmann

2. Bioequivalence . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23 Panos Macheras, Christos Reppas, and Mira Symillides

3. Cutaneous and Transdermal Delivery-Processes and Systems

of Delivery . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 43 Guang Wei Lu and Gordon L. Flynn

4. Design and Evaluation of Ophthalmic Pharmaceutical Products . . . . 101 Paul J. Missel, John C. Lang, Denise P. Rodeheaver, Rajni Jani,

Masood A. Chowhan, James Chastain, and Terry Dagnon

5. Delivery of Drugs by the Pulmonary Route . . . . . . . . . . . . . . . . . . . . 191 Anthony J. Hickey and Heidi M. Mansour

6. Pediatric and Geriatric Pharmaceutics and Formulation . . . . . . . . . . 221 Jo¨rg Breitkreutz and Catherine Tuleu

7. Biotechnology-Based Pharmaceuticals . . . . . . . . . . . . . . . . . . . . . . . . 259 Lene Jorgensen, Hanne Moerck Nielsen, and Sven Frokjaer

8. Veterinary Pharmaceutical Dosage Forms . . . . . . . . . . . . . . . . . . . . . 293 Michael J. Rathbone and Todd P. Foster

9. Target-Oriented Drug Delivery Systems . . . . . . . . . . . . . . . . . . . . . . 329 Vijay Kumar

10. New Imaging Methods for Dosage Form Characterization . . . . . . . . . 399 Colin D. Melia, Barry Crean, Samuel R. Pygall, and Hywel D. Williams

11. Aspects of Pharmaceutical Physics . . . . . . . . . . . . . . . . . . . . . . . . . . 421 Go¨ran Frenning and Go¨ran Alderborn

12. Pharmaceutical Aspects of Nanotechnology . . . . . . . . . . . . . . . . . . . . 453 Alexander T. Florence

13. Dosage Forms for Personalized Medicine: From the Simple to the

Complex . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 493 Alexander T. Florence and Juergen Siepmann

Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 513