ABSTRACT

Dopamine β-hydroxylase, EC 1.14.17.1, is a copper-containing enzyme that catalyzes the conversion of dopamine (Structure 10.1) to norepinephrine (Structure 10.2) (Figure 10.1). Because norepinephrine raises blood pressure but dopamine does not, we were interested in inhibitors of this enzyme for use as potential antihypertensives.