Drugs on the Horizon and Drugs Relegated to History
Ninewells Hospital and Medical School, Dundee, Scotland
George A. Bray Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, U.S.A.
C Leptin Resistance
Table 1 Contrast Between Leptin Deficiency and Resistance inMan
of over 3 years. Strobel et al. (11) have described a Turkish family with three siblings with leptin deficiency attributable to a missense mutation in the leptin gene. These sisters did not undergo pubertal development with hormonal features of hypogonadotropic hypogonadism. Leptin reverses the obesity and induces puberty. However, these are very rare instances, and the majority of the obese appear to have elevated leptin levels compared to the lean, suggesting that there is some resistance to leptin at the brain level (12).