ABSTRACT
Preface to the Second Edition iii Preface to the First Edition v Contributors xi
PART I HISTORY, DEFINITIONS, AND PREVALENCE
1. Historical Framework for the Development of Ideas About Obesity 1 George A. Bray
2. Evaluation of Total and Regional Adiposity 33 Steven B. Heymsfield, Richard N. Baumgartner, David B. Allison, Wei Shen, ZiMian Wang, and Robert Ross
3. Ethnic and Geographic Influences on Body Composition 81 Paul Deurenberg and Mabel Deurenberg-Yap
4. Prevalence of Obesity in Adults: The Global Epidemic 93 Jacob C. Seidell and Aila M. Rissanen
5. Fetal Origins of Obesity 109 David J. P. Barker
6. Pediatric Overweight: An Overview 117 Bettylou Sherry and William H. Dietz
7. Obesity in the Elderly: Prevalence, Consequences, and Treatment 135 Robert S. Schwartz
8. Economic Costs of Obesity 149 Ian D. Caterson, Janet Franklin, and Graham A. Colditz
PART II ETIOLOGY
9. Genetics of Human Obesity 157 Claude Bouchard, Louis Pe´russe, Treva Rice, and D. C. Rao
vii
10. Molecular Genetics of Rodent and Human Single Gene Mutations Affecting Body Composition 201 Streamson Chua, Jr., Kathleen Graham Lomax, and Rudolph L. Leibel
11. Rodent Models of Obesity 255 David A. York
12. Primates in the Study of Aging-Associated Obesity 283 Barbara C. Hansen
13. Behavioral Neuroscience and Obesity 301 Sarah F. Leibowitz and Bartley G. Hoebel
14. Experimental Studies on the Control of Food Intake 373 Henry S. Koopmans
15. Diet Composition and the Control of Food Intake in Humans 427 John E. Blundell and James Stubbs
16. Central Integration of Peripheral Signals in the Regulation of Food Intake and Energy Balance: Role of Leptin and Insulin 461 L. Arthur Campfield, Francoise J. Smith, and Bernard Jeanrenaud
17. Development of White Adipose Tissue 481 Ge´rard Ailhaud and Hans Hauner
18. Lipolysis and Lipid Mobilization in Human Adipose Tissue 515 Dominique Langin and Max Lafontan
19. Lipodystrophy and Lipoatrophy 533 Steven R. Smith
20. Uncoupling Proteins 539 Daniel Ricquier and Leslie P. Kozak
21. Peroxisome Proliferator-Activated Receptor g and the Transcriptional Control of Adipogenesis and Metabolism 559 Lluis Fajas and Johan Auwerx
22. Biology of Visceral Adipose Tissue 589 Susan K. Fried and Robert R. Ross
23. Resting Energy Expenditure, Thermic Effect of Food, and Total Energy Expenditure 615 Yves Schutz and Eric Je´quier
24. Energy Expenditure in Physical Activity 631 James O. Hill, W. H. M. Saris, and James A. Levine
25. Endocrine Determinants of Obesity 655 Jonathan H. Pinkney and Peter G. Kopelman
26. Endocrine Determinants of Fat Distribution 671 Renato Pasquali, Valentina Vicennati, and Uberto Pagotto
27. Sympathoadrenal System and Metabolism 693 Eric Ravussin and Ian Andrew Macdonald
28. Energy Expenditure and Substrate Oxidation 705 Jean-Pierre Flatt and Angelo Tremblay
29. Skeletal Muscle and Obesity 733 David E. Kelley and Len Storlien
30. Nutrient Partitioning 753 Samyah Shadid and Michael D. Jensen
PART III PATHOPHYSIOLOGY
31. Obesity and Mortality Rates 767 Kevin R. Fontaine and David B. Allison
32. Etiology of the Metabolic Syndrome 787 Per Bjo¨rntorp
33. Obesity as a Risk Factor for Major Health Outcomes 813 JoAnn E. Manson, Patrick J. Skerrett, and Walter C. Willett
34. Effects of Obesity on the Cardiovascular System 825 Edward Saltzman and Peter N. Benotti
35. Obesity and Lipoprotein Metabolism 845 Jean-Pierre Despre´s and Ronald M. Krauss
36. Obesity and Blood Pressure Regulation 873 Albert P. Rocchini
37. Obesity and Diabetes 899 Jeanine Albu and F. Xavier Pi-Sunyer
38. Obesity and Gallbladder Disease 919 Cynthia W. Ko and Sum P. Lee
39. Obesity and Pulmonary Function 935 Shyam Subramanian and Kingman P. Strohl
40. Obesity, Arthritis, and Gout 953 Anita Wluka, Tim D. Spector, and Flavia M. Cicuttini
41. Obesity, Pregnancy, and Infertility 967 Stephan Ro¨ssner
42. Physical Activity, Obesity, and Health Outcomes 983 William J. Wilkinson and Steven N. Blair
43. Obesity and Quality of Life 1005 Donald A. Williamson and Patrick M. O’Neil
Index 1023
