Cardiovascular disease is the leading cause of death in industrialized countries, and in the United States, cardiovascular disease accounts for f50% of all deaths (1). Obesity increases risk for coronary heart disease (CHD), congestive heart failure (CHF), arrhythmia, sudden death, and several other cardiovascular diseases (Table 1). Obesity promotes several traditional risk factors for cardiovascular disease, and in addition considerable attention has been devoted to deﬁning the pathogenic role of excess weight that is independent of traditional risk factors. Obesity has recently been found to be associated with several nontraditional risk factors, such as disturbances in ﬁbrinolysis, impaired endothelial function, and chronic low-grade inﬂammation. Regardless of themechanism, it is clear that obesity is associated with deleterious eﬀects on the heart and circulatory system.