chapter  35
28 Pages

Obesity and Lipoprotein Metabolism

The measurement of plasma lipid levels is now commonly used to assess the risk of coronary heart disease (CHD). Several epidemiological studies have shown that there is a significant positive relationship between blood cholesterol levels and deaths associated with CHD (1-3). In the Multiple Risk Factor Intervention Trial (MRFIT), Stamler et al. (4) showed that in a sample of 356,222male subjects, increased blood cholesterol levels were associated with a progressive increase in CHD mortality. However, despite the fact that numerous studies have shown this relationship, Genest et al. (5) have reported that nearly 50% of patients having ischemic heart disease (IHD) have plasma cholesterol levels equal to or even lower than those of healthy subjects.