ABSTRACT
Next to Alzheimer’s disease (AD), sporadic Parkinson’s disease (PD) is the most frequent synucleinopathy and neurodegenerative disorder of the human brain1,2 (see also Chapter 4). It is not known to affect other species of vertebrates, and, provided it is not terminated by death from other causes, it can progress over decades.3 Unlike AD, however, the pathological process driving sporadic PD develops within multiple central and peripheral subdivisions of the human nervous system (see also Chapter 39).
