Chapter Kinetics of Folate and One-Carbon Metabolism

I. Introduction .................................................................................................. 491 II. Kinetic Aspects of Intervention Studies with Controlled Diets or

Folate Supplements ....................................................................................... 492 A. Controlled Diets ....................................................................................... 492 B. Unlabeled Supplements ............................................................................ 493

1. Short-Term Kinetics ............................................................................. 493 2. Long-Term Kinetics ............................................................................. 494

III. Kinetic Analysis with Isotopic Tracers......................................................... 497 A. Experimental Approaches and Rationale ............................................... 497 B. Knowledge of Folate Metabolism Derived from Studies

Using Folate Tracers ................................................................................ 499 1. Physiological Aspects .......................................................................... 499 2. Clinical Applications of Folate Kinetics in Human Nutrition ............. 501 3. Stable Isotopic Investigations of Folate Kinetics .................................502