ABSTRACT
AEDs Eliminated Renally ....................................................................................... 17 AEDs Eliminated by CYP-Dependent Metabolism ................................................ 18 AEDs Eliminated by UGT-Dependent Hepatic Metabolism ................................... 19 AEDs Eliminated by Mixed CYP, UGT, and Other Metabolic Pathways ..............20 AEDs Eliminated by Hepatic Metabolism and Renal Excretion ............................ 21 Conclusion ................................................................................................................22 References ................................................................................................................24
Many age-related variables inuence the pharmacokinetic properties of drugs.37 For example, with respect to absorption, gastric pH is increased in neonates, infants, and young children, but decreases to adult levels after 2 years of age. Gastric and intestinal motility is decreased in neonates and infants, but is increased in older infants and children to comparable adult levels. Very few studies have evaluated the maturation of the rate and extent of absorption; however, it is generally accepted that the absorption rate of drugs is lower in neonates and young infants compared to older children. There is little or no information regarding the maturation of active transporters in the gastrointestinal tract that are known to signicantly affect the bioavailability of certain drugs.
