ABSTRACT
Th e problem of maintaining adhesion contact stability between an adhesive and skin during patch wear has particular signifi cance in the design and application of transdermal drug delivery systems (TDS). Transdermal patches are designed for extended wear (∼1-7 days) application to human skin. In this chapter we fi rst describe the mechanisms of pressure-sensitive adhesive (PSA)–skin interactions and, based on experimental results, off er a quantitative approach for the prediction of skin wear time of various types of PSAs.
