chapter  20
40 Pages

Airway Remodeling as the Outcome of a Chronic Immune Response to Inhaled Allergen

The regeneration process in asthma follows the natural course of chronic in£ammation and results in either tissue repair (a tightly regulated salutary biological response) or abnormal remodeling (an unregulated pathological process).This appears to beheterogeneous, leading, through a dynamic process of cell dedi¡erentiation, migration, di¡erentiation, and maturation, to changes in connective tissue deposition (5). Although remodeling processes are almost invariably found in the airways of asthmatics, the extent of remodeling in asthma and its clinical consequences are still a matter of debate.