ABSTRACT
It is well known that there is an abnormal growth of neovasculature in solid tumors. These vessels typically form an inefcient and leaky network of blood vessels, thereby constraining delivery of oxygen and other nutrients to the cancer cells [1]. This inefcient system of oxygen delivery combined with the high metabolic demand within the proliferating cancer cells drives a feedback cycle that further propagates aberrant angiogenesis. Both hypoxia and angiogenesis have been •agged as indicators of cancer, and hypoxic microenvironments have been identied in solid tumors of many different tissues [2].
