ABSTRACT
ErbB heterodimers with homodimers having signicantly less activity [1,2]. e individual dimers are selective for activating the various signaling cascades [1]. In contrast to this ligand specicity of ErbB receptor activation, ionizing radiation is promiscuous, inducing the activation of all ErbB receptors within minutes of exposure to doses in the range of 2 Gy [3,4]. Because the ErbB receptors are important in tumor cell survival, their rapid response to radiation indicates a protective role in the cellular radioresponse and strongly suggests RTKs as a target for radiosensitization [3,4].
