ABSTRACT
Autosomal dominant nocturnal frontal lobe epilepsy (NFLE) is associated with a defect in the alpha 4 subunit of the nicotinic acetylcholine-gated ion channel (Mann and Mody 2008). Since the engine for neuronal excitability is the membrane ion channel, it is not surprising that there would be a relationship between epilepsy and ion channel abnormalities. The puzzle arises because the ion channel abnormality is a –xed de–cit, yet seizures are paroxysmal events.
