ABSTRACT

About 50 million people in the world are suffering from epilepsy, 30% of whom are resistant to all medical therapies (Kwan and Brodie 2000). Although the drugs and devices pertinent to this disease have advanced over time, the percentage of patients who experience a decrease in seizure frequency has not corresponded proportionally. Only about 60% of the patients on medication and 35% of the patients using the vagal nerve stimulator have experienced a decrease in seizure frequency. One of the prominent treatment measures for patients with severe refractory seizures is surgery to cut away brain tissue that contains the seizure focus (resection) or disconnecting the corpus callosum to prevent the spread of seizures (callosotomy). A working algorithm that can predict seizures holds immense promise for such patients, as it will allow them to take appropriate precautions keeping the risk of a seizure attack to a minimum.