ABSTRACT

Activated attapulgite Nontoxic Amphotericin LD50 88.0 g/kg intraperitoneal mouse Acyclovir LD50 20.0 g/kg oral rat; LD50 10.0 g/kg oral mouse Acebutolol hydrochloride LD50 6620.0 g/kg oral rat Acetazolamide LD50 4300 mg/kg oral mouse Albendazole LD50 2400.0 mg/kg oral rat Aluminum hydroxide LD50 9500 mg/kg oral rat Alprostadil LD50 186.0 mg/kg oral mouse Alprenolol hydrochloride LD50 590.0 mg/kg oral rat Amantadine hydrochloride LD50 700.0 mg/kg oral mouse Ambroxol hydrochloride LD50 13,400.0 mg/kg oral rat Amiodarone LD50 2600.0 mg/kg oral rat Ammonium chloride LD50 1650.0 mg/kg oral rat Amoxicillin LD50 15.0 g/kg oral rat; LD50 25 g/kg oral mouse Ampicillin trihydrate LD50 10,000 mg/kg oral rat Amikacin sulfate LD 50 >6000 mg/kg oral mouse Aminophylline LD50 243 mg/kg oral rat Aspirin LD50 200 mg/kg oral rat Astemizole LD50 2560.0 g/kg oral rat; LD50 2560.0 g/kg oral mouse Atropine sulfate LD50 600 mg/kg oral rat Atenolol LD50 2000.0 mg/kg oral mouse/rat Azithromycin dihydrate LD50 2.0 g/kg oral rat; LD50 3.0 g/kg oral mouse Betamethasone valerate LD50 3.0 g/kg oral rat; LD50 4067 mg/kg oral mouse Bacitracin USP LD50 3750.0 mg/kg oral mouse Bacampicillin hydrochloride LD50 10,000.0 g/kg oral rat Bisacodyl LD50 4320 mg/kg oral rat Beclomethasone dipropionate LD50 3750.0 mg/kg oral rat

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Active Ingredients Toxicity

Betaxolol hydrochloride LD50 998.0 mg/kg oral rat; LD50 48.0 mg/kg oral mouse Bezafi brate LD50 1082.0 mg/kg oral rat Benzocaine LD50 1150.0 mg/kg oral rabbit Benzalkonium chloride LD50 240.0 mg/kg oral rat Bromhexine HCl LD50 1226 mg/kg oral rat Bifonazole LD50 1463.0 mg/kg oral rat; LD50 2629.0 mg/kg oral mouse Budesonide LD50 4750.0 mg/kg oral mouse Buprenorphine hydrochloride LD50 1000 mg/kg oral rat Bufexamac LD50 3370.0 mg/kg oral rat; LD50 8000.0 mg/kg oral mouse Bupivacaine hydrochloride LD50 43 mg/kg subcutaneous rat Calcium pantothenate LD50 10 g/kg oral rat Caffeine LD50 127 mg/kg oral mouse Carbamazepine LD50 1957 mg/kg oral rat Carbinoxamine LD50 162 mg/kg oral mouse Carbachol LD50 40.0 mg/kg oral rat; LD50 15.0 mg/kg oral mouse Captopril LD50 4245 mg/kg oral rat Carbidopa LD50 1750 mg/kg oral mouse Cetylpyridinium chloride LD50 200.0 mg/kg oral rat; LD50 108.0 mg/kg oral mouse Calcitriol LD50 0.62 mg/kg oral rat Calcium ascorbate LD50 14,500.0 mg/kg oral rat; LD50 1600.0 mg/kg oral mouse Cinnarizine theophyllinate LD50 6500.0 g/kg oral rat; LD50 4500.0 mg/kg oral mouse Clobetasol propionate LD50 3.0 g/kg oral rat; LD50 3.0 mg/kg oral mouse Cephalexin monohydrate LD50 1495 mg/kg oral mouse Cefaclor monohydrate LD50 >20,000 g/kg oral rat Cefi xime Nontoxic Cefazolin sodium LD50 11,000.00 mg/kg oral rat Ceftazidime LD50 >20,000 mg/kg oral rat Cefuroxime axetil LD50 5000 mg/kg oral rat Cefotaxime LD50 20,000.00 mg/kg oral rat Ceftriaxone LD5010.0 g/kg oral rat and oral mouse Cetirizine HCl LD50 703.0 mg/kg oral rat Cephradine LD50 5000 mg/kg oral mouse Chlorpheniramine maleate LD50 130 mg/kg oral mouse; LD50 300 mg/kg oral rat Chlorambucil LD50 80 mg/kg oral mouse; LD50 76 mg/kg oral rat Chloramphenicol LD50 2500 mg/kg oral rat; LD50 1500.0 mg/kg oral mouse Chlorcyclizine hydrochloride LD50 300 mg/kg oral mouse Chlorhexidine LD50 9200 μL/kg oral rat Chlorpromazine LD50 145.0 mg/kg oral rat; LD50 135.0 mg/kg oral mouse Ciclopirox LD50 2350 mg/kg oral rat Cimetidine LD50 5000 mg/kg oral rat Cincochain HCl LD50 42 mg/kg oral bird Ciprofl oxacin LD50 5000 mg/kg oral rat; LD50 5000 mg/kg oral mouse

Active Ingredients Toxicity

Clarithromycin LD50 2700 mg/kg oral rat Clavulanate potassium LD50 5000 mg/kg oral rat Clobutinol HCl LD50 802 mg/kg oral rat Codeine phosphate LD50 85 mg/kg oral rat Colchicine LD50 5886 μg/kg oral mouse Cloxacillin sodium LD50 5000 mg/kg oral rat Cyanocobalamin LD50 2 g/kg oral mouse Cyclosporine LD50 15,800 mg/kg oral rabbit Dextromethorphan HBr LD50 350 mg/kg oral rat Diphenhydramine HCl LD50 500 mg/kg oral rat Diclofenac sodium LD50 390 mg/kg oral mouse; LD50 150 mg/kg oral rat Difl unisal LD50 392 mg/kg oral mouse; LD50 439 mg/kg oral rat Diethylcarbamazine citrate LD50 660 mg/kg oral mouse; LD50 1400 mg/kg oral rat Dexpanthenol LD50 15,000 mg/kg oral mouse Diazepam LD50 48 mg/kg oral mouse Dimenhydrinate LD50 681 mg/kg oral rat Diphenoxylate HCl LD50 221 mg/kg oral rat Doxycycline hyclate LD50 1900.0 g/kg oral mouse Ephedrine HCl LD50 710 mg/kg oral rat Enalapril maleate LD50 2973 mg/kg oral rat Erythromycin LD50 10.0 g/kg oral mouse Etodolac LD50 95 mg/kg oral rat Famotidine LD50 4049 mg/kg oral rat Felodipine LD50 1050 mg/kg oral rat Fenoprofen calcium LD50 439 mg/kg oral mouse; LD50 415 mg/kg oral rat Fluxetine HCl LD50 452 mg/kg oral rat Fluticasone propionate LD50 2000 mg/kg oral rat Fluvoxamine maleate LD50 1100.0 mg/kg oral mouse Flutamide LD50 787 mg/kg oral rat Folic acid LD50 8000 mg/kg oral rat Fusidic acid LD50 975.0 mg/kg oral mouse Flunitrazepam LD50 415 mg/ kg oral rat Flutamide LD50 787 mg/kg oral rat Fluvoxamine maleate LD50 1100.0 mg/kg oral mouse Ferrous sulfate (dried) LD50 1520 mg/kg oral mouse Ferrous fumarate LD50 3850 mg/kg oral rat Furosemide LD50 2600 mg/kg oral rat Gemfi brozil LD50 1414 mg/kg oral rat Ginseng LD50 750 mg/kg oral rat Glibenclamide LD50 >20,000 mg/kg oral rat Gliclazide LD50 3000 mg/kg oral rat Glycerin LD50 17 g/kg oral rat

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Active Ingredients Toxicity

Glyceryl guaiacolate LD50 12600 mg/kg oral rat Gramicidin LD50 1000 mg/kg oral mouse Heparin calcium LD50 >200 KU/kg oral rat; LD50 >400 KU/kg oral mouse Hydrocortisone LD50 150 mg/kg oral rat Hyoscine-N-butyl bromide LD50 1170 mg/kg oral mouse; LD50 1040 mg/kg oral rat Ibuprofen LD50 636 mg/kg oral rat; LD50 740 mg/kg oral mouse Indapamide LD50 >3000 mg/kg oral rat Indomethacin LD50 2.42 mg/kg oral rat Kaopectate LD50 >5000 mg/kg oral rat Ketotifen fumarate LD50 360 mg/kg oral rat; LD50 585 mg/kg oral mouse Ketoconazole LD50 166.0 mg/kg oral rat; LD50 618 mg/kg oral mouse Lamotrigine LD50 185 mg/kg oral rat; LD50 269 mg/kg oral mouse Lomefl oxacin HCl LD50 1556 mg/kg oral rat Loratadine LD50 >5000 mg/kg oral rat Levofl oxacin LD50 35,900 mg/kg oral rat; LD50 3366 mg/kg oral mouse Lidocaine HCl LD50 292 mg/kg oral mouse Magnesium aluminum silicate LD50 16,000 mg/kg oral rat Magnesium hydroxide LD50 8500 mg/kg oral rat Miconazole nitrate LD50 920 mg/kg oral rat; LD50 578 mg/kg oral mouse Mebendazole LD50 714 mg/kg oral rat; LD50 620 mg/kg oral mouse Menthol LD50 3300 mg/kg oral rat Metronidazole LD50 3000 mg/kg oral rat Metoclopramide HCl LD50 280 mg/kg oral mouse Metformin HCl LD50 4000 mg/kg oral rat Nifedipine LD50 1022 mg/kg oral rat Nicotinamide LD50 3500 mg/kg oral rat Norfl oxacin LD50 >4000 mg/kg oral rat Nystatin topical LD50 10,000 mg/kg oral rat; LD50 8000 mg/kg oral mouse Neomycin sulfate LD50 8.0 g/kg oral mouse Omeprazole LD50 2210 mg/kg oral rat; LD50 4.0 g/kg oral mouse Orphenadrine citrate LD50 150 mg/kg oral mouse Orciprenaline sulfate LD50 5538 mg/kg oral rat Orphenadrine hydrochloride LD50 255 mg/kg oral rat Oxazepam LD50 >8000 mg/kg oral rat Oxybuprocaine HCl N/A Oxymetazoline HCl LD50 0.88 mg/kg oral rat Oxytetracycline LD50 4700 mcg/kg oral mouse; LD50 680 mcg/kg oral rat Paracetamol LD50 2404 mg/kg oral rat Papaverine hydrochloride LD50 68.8 mg/kg oral rat Paroxetine HCl hemihydrate LD50 374 mg/kg oral rat; LD50 341 mg/kg oral mouse Penicillamine LD50 3670 mg/kg oral mouse Pentoxifylline LD50 1170 mg/kg oral rat

Active Ingredients Toxicity

Phenobarbital sodium LD50 150 mg/kg oral rat Phenylephrine HCl LD50 350 mg/kg oral rat Phenylalanine Not known Piperazine citrate LD50 11,200 mg/kg oral rat Propranolol HCl LD50 466 mg/kg oral rat Prazosin hydrochloride LD50 1950 mg/kg oral rat Prednisolone LD50 1680 mg/kg oral mouse Promethazine HCl LD50 255 mg/kg oral rat Procaine hydrochloride LD50 184 mg/kg IP rat; LD50 180 mg/kg IP mouse Pheniramine maleate LD50 520 mg/kg oral rat Pseudoephedrine HCl LD50 202 mg/kg IP mouse Ranitidine HCl LD50 >5 mg/kg oral rat; LD50 884 mg/kg Recombinant human erythropoietin N/A Resorcinol LD50 301 mg/kg oral rat Rifampicin Not known Risperidone LD50 56.6 mg/kg oral rat Salbutamol sulfate LD50 1950 mg/kg oral mouse; LD50 2500 mg/kg oral rat Salicylamide LD50 1700 mg/kg oral rat Salicylic acid LD50 1500 mg/kg oral mouse; LD50 700 mg/kg oral rat Sertaconazole nitrate Not available Silver sulfadiazine LD50 1000 mg/kg oral rat Simvastatine sodium LD50 4438 mg/kg oral rat; LD50 3.0 g/kg oral mouse Sodium alendronate Not available Sodium citrate Not known Sodium valproate LD50 870 mg/kg oral rat Sodium iodide LD50 4340 mg/kg oral rat Somatostatin LD50 21 mg/kg IV rat; LD50 33 mg/kg IV mouse Simethicone LD50 2000 mg/kg oral rat Sucralfate LD50 12 g/kg oral rat Succinylsulfathiazole LD50 10 g/kg IV rat; LD50 5700 mg/kg IP mouse Tamoxifene citrate LD50 1190 g/kg oral rat Tetracycline HCl LD50 6443 mg/kg oral rat; LD50 2759 mg/kg oral mouse Theophylline LD50 666 mg/kg oral rat Tribenoside LD50 10.0 mg/kg oral rat Triamcinolone acetonide LD50 5000 mg/kg oral mouse Triprolidine HCl LD50 840 mg/kg oral rat; LD50 495 mg/kg oral mouse Trimethoprim LD50 >5300 mg/kg oral rat; LD50 2764 mg/kg oral mouse Tyrothricin LD50 >3000 mg/kg oral mouse Xylometazoline LD50 230.0 mg/kg oral rat Vancomycin HCl LD50 10.0 g/kg oral rat; LD50 5.0 g/kg oral mouse

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Active Ingredients Toxicity

Verapamil hydrochloride LD50 108.0 mg/kg oral rat Vitamin A LD50 7910 mg/kg oral rat; LD50 6060 mg/kg oral mouse Vitamin D LD50 2000 mg/kg oral rat Vitamin C LD50 11,900 mg/kg oral rat Vitamin B1 LD50 10,000 mg/kg oral rat and oral mouse Vitamin B2 LD50 20,000 mg/kg oral rat Vitamin B6 LD50 5500 mg/kg oral mouse; 4000 mg/kg oral rat Vitamin B12 LD50 8000 mg/kg oral mouse Xylometazoline hydrochloride LD50 230 mg/kg oral rat; LD50 75 mg/kg oral mouse Zinc oxide LD50 >8437.0 mg/kg oral rat; LD50 7950 mg/kg oral mouse