ABSTRACT
As in other vascular beds, the endothelium of the renal vasculature synthesises mediators such as NO, prostaglandins and endothelin with potential to modulate blood vessel function. However, the endothelium is not the only cell type that synthesises these autacoids, and many renal parenchymal cells synthesise and respond to these mediators. This makes it difficult to be certain of the precise contribution of the endothelium to effects mediated by these agents. Moreover, the kidney is also responsible for the excretion of substances that might alter endothelial function, and as a result renal dysfunction could contribute to widespread endothelial abnormalities. In this chapter, we will review the role of endothelial mediators in the regulation of renal function with emphasis on human physiology and pathophysiology.
