ABSTRACT
Regulation of blood cell behaviour is a major endothelial function that ensures blood fluidity. The endothelium actively supports the fluid state of flowing blood and prevents activation of circulating cells. This ability must be carefully balanced against the homeostatic property of blood that is meant to protect the vascular system from loss of blood due to an accidental breach of vascular integrity. These diverse, yet co-ordinated, reactions are often referred to as vascular haemostasis. Thrombosis is a pathological extension of haemostasis that takes place when the regulatory mechanisms are inadequate.
