ABSTRACT
Figure 11 Evaluation of C. immitis urease as candidate vaccine antigen. (A) Detection of urease protein in total cell homogenates of different stages of parasitic cycle by immunoblot analysis using antiserum raised to purified recombinant protein (rURE). (B, C) Immunoprotective efficacy of rURE plus adjuvant (CpG-ODNIIFA) based on residual fungal burden in lungs and spleen (B) and survival of mice (C) after IP challenge (50 viable arthroconidia; 735 strain).
