ABSTRACT
Functions
MHC class I-like molecule, associated with p2-microglobulin. May have specialized role in antigen presentation
Adhesion molecule, binding CD58 (LFA-3), can activate Tcells
Activation-sensitive conformational form of CD2
Associated with the T-cell antigen receptor, required for cell surface expression of and signal transduction by TCR
Coreceptor for MHC class II molecules, binds lck on cytoplasmic face of membrane, receptor for HIV-I and HIV-2 gpl20
Molecular* weight (kD)
43-49
45-48
45-58
g: 25-28 d: 20 e: 20 z: 16 h: 22
Cellular expression
Cortical thymocytes, Langerhans cells, dendritic cells, Bcells (CDlc), intestinal epithelium (CDId)
T cells, thymocytes, NK cells
T cells
Thymocytes, Tcells
Thymocyte subsets, helper and inflammatory Tcells (about two-thirds of peripheral T cells), monocytes, macrophages
CD antigen
CDla,b,c,d
CD2
CD2R
CD3
CD4
A ntigenD
esignations 299
Scavenger receptor
IgSF
IgSF
Tetraspanning membrane protein
T12
T8, Lyt2,3
Neutral endopeptidase, common acute lymphocytic leukemia antigen (CALLA)
CD 166
Unknown, marker for T cell ALL and pluripotential stem cell leukemias
Coreceptor for MHC class Imolecules, binds Ick on cytoplasmic face of membrane
Possible role in platelet aggregation and activation
Zinc metalloproteinase, marker for pre-B ALL
100-130
a: 32-34 b: 32-34
22-27
subset of Bcells
Thymocytes, Tcells, B cell CLL
Pluripotential hematopoietic cells, thymocytes, Tcells
Thymocyte subsets, cytotoxic Tcells (about one-third of peripheral Tcells)
Pre-B cells, eosinophils, basophils, platelets, monocyte
B-and T-cell precursors, bone marrow stromal cells
CD6
CD7
CD8
CD9
CD10
A
ppendixB
Family relationshipsOther names
LFA-1
Mac-1
CR4, pi 50, 95
Aminopeptidase N
Functions
ah subunit of integrin LFA-1 (associated with CD 18); binds to CD54 (ICAM-1), ICAM-2, and ICAM-3
aM subunit of integrin CR3 (associated with CD18); binds CD54, complement component iC3b, and extracellular matrix proteins
aX subunit of integrin CR4 (associated with CD 18); binds fibrinogen
Unknown
Zinc metalloproteinase Receptor for complex of
LPS and LPS binding protein (LBP)
Molecular* weight (kD)
90-120
150-170 53-55
Cellular expression
Lymphocytes, granulocytes, monocytes, and macrophages
Myeloid and NK cells
Myeloid cells
Monocytes, granulocytes, platelets
Myelomonocytic cells Myelomonocytic cells
CD antigen
CDlla
CDllb
CDllc
CDwl2
CD13 CD14
A ntigenD
esignations 301
IgSF
IgSF
Tetraspanning membrane protein
FcgRni
saccharide, expressed on glycolipids and many cell surface glycoproteins; the sialylated form is a ligand for CD62E (ELAM)
Component of lowaffinity Fc receptor, FcyRIII, mediates phagocytosis and ADCC
Lactosyl ceramide, acell surface glycosphingolipid
Integrin p2 subunit, associates with CDlla, b, and c
Forms complex with CD21 (CR2) and CD81 (TAPA-1), coreceptor for Bcells
Possible role in regulating B-cell activation
50-80
33-37
monocytes
Neutrophils, NK cells, macrophages
Neutrophils, monocytes, platelets
Leukocytes
B cells
B cells
CD16
CDwl7
CD18
CD19
CD20
A
ppendixB Family
relationships
CCP superfamily
IgSF
C-type lectin
a: CCP b: cytokine receptor superfamily
NGF receptor superfamily
Other names
CR2
BL-CAM
FcyRII
Possible human homologue of mouse heatstable antigen or Jlld .
