ABSTRACT
NATALIA JAWORSKA, FRANK P. MACMASTER, ISMAEL GAXIOLA, FILOMENO CORTESE, BRADLEY GOODYEAR, AND RAJAMANNAR RAMASUBBU
5.1 INTRODUCTION
Major depressive disorder (MDD) is a common psychiatric disorder with a high burden of disease, yet its neural underpinnings remain elusive. A handful of studies have assessed spatial patterns of cortical thickness in MDD. Interestingly, the regional patterns of cortical thinning in MDD do not perfectly reflect what would be expected from the neuroimaging literature (i.e., cortical thinning is not confined to cognitive and emotive centers; fronto-cortico-limbic structures) [1]. Further, extant literature is not consistent with respect to which cortical regions are typically thicker/ thinner in the disorder. This indicates a need for further study with careful
attention to factors that may influence cortical thickness in MDD, such as age of disorder onset and past trauma and neglect.
