ABSTRACT

This chapter highlights the versatility of mass spectrometry (MS) in environmental applications when coupled with other very inno-vative proteomic techniques such as the nucleic acid programmable protein arrays (NAPPA) and fluorescence microscope analysis. We summarize the results obtained through the labeled and label-free detection of NAPPA-investigated by different mass spectrometry techniques. Two kinds of NAPPA arrays have been analyzed, GSTNAPPA and SNAP-NAPPA, the latter specifically designed for MS analysis.