ABSTRACT
Male pattern hair loss (MPHL) aects up to 80% of men in the course of their life and is caused by a progressive reduction in the diameter, length, and pigmentation of the hair. Hair thinning is limited to the frontal, temporal, and vertex areas (androgen-dependent scalp regions) and results from the eects of the testosterone metabolite dihydrotestosterone (DHT) on androgen-sensitive hair follicles. Androgen sensitivity is genetically determined and depends on DHT production through 5-alpha reductase enzymes.
