ABSTRACT
Vascular biology, endothelial and vascular smooth muscle, and cardiac dysfunction play a primary role in the initiation and perpetuation of hypertension, cardiovascular disease (CVD), and targetorgan damage (TOD). Nutrient-gene interactions and epigenetics are predominant factors in promoting benecial or detrimental effects in cardiovascular health and hypertension. Macronutrients and micronutrients may be able to prevent, control, or treat hypertension through numerous mechanisms related to vascular biology or other mechanisms. Oxidative stress, inammation, and autoimmune dysfunction are some of the primary factors that initiate and propagate hypertension and CVD. The literature suggests that there may be a complementary role of single and component nutraceutical supplements, vitamins, antioxidants, and minerals in the treatment of hypertension when combined with optimal nutrition and other lifestyle modications. However, many of these studies are small and do not have long-term follow-up for efcacy and safety. The role of these nutrition and nutraceutical supplements will require a careful review and additional studies to determine their exact role in the management of hypertension.
