ABSTRACT

Abstract .................................................................................................................. 238 Introduction ............................................................................................................ 238 Mitophagy Protects against Liver Injury................................................................ 239

Mitochondrial Fission and Fusion and Mitophagy ........................................... 239 Mitophagy Prevents Apoptosis and Necrosis .................................................... 241 Mitophagy Maintains Mitochondrial Bioenergetics .........................................242 Mitophagy Maintains FA Oxidation ................................................................. 243 Mitophagy and Mitochondrial Biogenesis Must Be Balanced .........................244

Current Mechanisms of Mitophagy .......................................................................246 Parkin-Dependent Mitophagy ...........................................................................246 Parkin-Independent Mitophagy .........................................................................248