ABSTRACT

All the Essentials to Start Using Adaptive Designs in No TimeCompared to traditional clinical trial designs, adaptive designs often lead to increased success rates in drug development at reduced costs and time. Introductory Adaptive Trial Designs: A Practical Guide with R motivates newcomers to quickly and easily grasp the essence of adaptive desig

chapter 1|10 pages

Introduction

chapter 2|14 pages

Classical Design

chapter 5|10 pages

Sample-Size Reestimation Design

chapter 6|18 pages

Special Two-Stage Group Sequential Trials

chapter 7|6 pages

Pick-the-Winners Design

chapter 8|18 pages

The Add-Arms Design

chapter 9|10 pages

Biomarker-Adaptive Design

chapter 10|6 pages

Response-Adaptive Randomization

chapter 11|10 pages

Adaptive Dose-Escalation Trial

chapter 12|8 pages

Deciding Which Adaptive Design to Use

chapter 13|4 pages

Monitoring Trials and Making Adaptations

chapter 14|6 pages

Data Analyses of Adaptive Trials

chapter 15|12 pages

Planning and Execution