ABSTRACT

Nonalcoholic fatty liver disease (NAFLD) has been recognized as a major health burden. Estimates suggest that about 20% to 30% of adults in developed countries have excess fat accumulation in the liver (Zelber-Sagi et al., 2006; Bedogni and Bellentani, 2004; Bellentani et al., 2000; Falck-Ytter et al., 2001; Propst et al.,

Obesity and Weight Gain .......................................................................................209 Nutritional Composition in the Prevention and Treatment of NAFLD .................. 210

Dietary Macronutrients ..................................................................................... 210 Type of Dietary Fat ....................................................................................... 211 n-3 Polyunsaturated Fatty Acids ................................................................... 211 Trans-Fatty Acids ......................................................................................... 212 Monounsaturated Fat .................................................................................... 212 Cholesterol ................................................................................................... 213 Added Sugar, Fructose, and Soft Drinks ...................................................... 214

Western Dietary Pattern and Fast Food ............................................................. 215 Different Weight Reduction Regimens in the Treatment of NAFLD..................... 216

Are Very Low Calorie Diets Effective? ............................................................. 216 Balanced Diets and Gradual Weight Reduction ................................................ 217 Are Low-Carbohydrate Diets Better than Low-Fat Diets? ............................... 218

How Much PA is Enough and Which Type is Most Effective? ............................. 219 Observational Studies ........................................................................................ 219 Clinical Trials with Aerobic Training ................................................................220 Clinical Trials with RT ......................................................................................220

Prevention is Better than Cure ............................................................................... 221 Summary and Implications .................................................................................... 221 References .............................................................................................................. 222