ABSTRACT

Statistical genetics is a scientific discipline that covers any statistical analysis of genetic data. The interplay between statistics and genetics has a long history, dating back to the seminal work by Fisher almost a century ago to confirm the genetic theory of chromosomal inheritance (Piegorsch, 1990). Recent advancements in genotyping (i.e., collecting genetic data) technologies have produced vast amounts of data, offering statisticians great opportunities in methodological development, implementation and application. For example, the high-dimensional genome-wide association studies conducted in the last few years have led to the development of a catalog of novel statistical methods for dissecting the genetic architecture of complex human traits; see, e.g., Thomas et al. (2009) and Begum et al. (2012).