ABSTRACT

Obesity has become a serious and growing public health problem [1]. Attempts to develop new therapeutic strategies have mostly focused on energy expenditure and caloric intake. Recent studies link energy homeostasis to the circadian clock at the behavioral, physiological, and molecular levels [2-5], emphasizing that certain nutrients and the timing of food intake may play a significant role in weight gain [6]. Therefore, it is plausible that resetting of the circadian clock can be used as a new approach to attenuate obesity.