ABSTRACT
Behcet's syndrome (BS) is an autoimmune disorder of unknown etiology. Although seen primarily through the Mediterranean to the Middle East, it has occurred worldwide. Human leukocyte antigen (HLA)-B51 is the most commonly associated genetic risk factor. An inflammatory reaction from Th-1, 2 and 17 T cells in response to a virus or bacteria with upregulation of ICAM-18 is the proposed mechanism for developing the clinical manifestations of the disease.
