ABSTRACT
In Disease Circulating monocytes can differentiate into macrophages if there is demand for phagocytosis in the blood. ® Nuclei become round to oval (Figure 8-2). ® Cytoplasm becomes more abundant. ® Vacuoles become more prominent and may contain phagocytized material of diagnostic significance (Figure 8-3): – Red blood cells in cases of immune-mediated hemolytic anemia. – Yeasts in diseases such as systemic histoplasmosis. – Protozoal forms in diseases such as leishmaniasis.
