ABSTRACT
The availability of the human genome sequence and the sequences of other species gave rise to hope that theywould lead to a new set of molecular markers of disease. Although a vast amount of information on human make up has been unlocked, in terms of the development of validated biochemical markers of disease and identification of new drug targets, the published results have been so far disappointing. However, this process has provided the impetus for wider searches for biomarkers of diseases and drug safety and theunderstanding that single simple markers of complex processes are unlikely to be definitive.
