ABSTRACT
The past two decades have seen an exponential increase in information from molecular studies of human and vertebrate pathobiology. Bioinformatics and high-throughput screening of genes, proteins, and their interactions have allowed the physician-scientist, for the first time, to shift gears from understanding the pathology of disease to the potential biological treatment of disease based on underlying molecular pathways. The genetic data from Mendelian forms of human disease have led to the discovery of novel gene pathways for complex developmental pathways including angiogenesis, organogenesis, and vertebrate patterning.
