ABSTRACT
Formulated pharmaceuticals are complex and often heterogeneous systems that
are difficult to analyze using standard analytical tools; this may be because the
object of the study is the active pharmaceutical ingredient (API), and any analysis
first requires its isolation from the rest of the medicine, or because the product
contains materials that are progressing through both chemical and physical
changes. In either case, isothermal calorimetry (IC) offers a potentially useful
alternative to conventional stability assessments because it simply monitors a
sample over time.