ABSTRACT
The skin is one of the largest organs of the human body. It is a highly specialized tissue that acts as a barrier against the influences of the environment. It plays a crucial role in the protection against dehydration and the control of body temperature (1). The skin’s primary role is to protect our health, but the skin’s barrier is imperfect and it also has the ability to absorb external substances. Moreover, these external substances can access healthy skin via its pilosebaceous glands. Drugs have been detected in the blood stream after topical application, demonstrating transdermal delivery through the skin (2). This is desired for the treatment of many skin diseases, but this characteristic can also be a contributing factor for causing many diverse health risks.
