ABSTRACT
In essence, this strategy (which is neither drug-nor organ-specific) “permits” normal tolerogenic interactions between donor and recipient leukocytes. However, alemtuzumab has provided more efficient and trouble-free lymphoid depletion than antithymocyte globulin
Immunosuppression
Time after Organ Transplantation
GVH
Recipient
Donor Failure
Failure
Success
HVG Immune Reaction
FIGURE 1 Contemporaneous HVG (upright curves) and GVH (inverted curves) responses following organ transplantation. In contrast to the usually dominant HVG reaction of organ transplantation, the GVH reaction usually is dominant after bone marrow cell transplantation to the irradiated or otherwise immunodepressed recipient. Therapeutic failure with either type of transplantation implies the inability to control one, the other, or both of the contemporaneous responses with a protective umbrella of immunosuppression. Abbreviations: GVH, graft versus-host; HVG, host-versus graft. Source: From Ref. 30.
