ABSTRACT

Drugs are most often introduced into the body by the oral route of administration. In fact, the vast majority of drug dosage forms are designed for oral ingestion, primarily for ease of administration. It should be recognized, however, that this route may result in inefficient and erratic drug therapy. Whenever a drug is ingested orally (or by any nonvascular route), one would like to have rapid and complete absorption into the bloodstream for the following reasons:

1. Assuming that there is some relationship between drug concentration in the body and the magnitude of the therapeutic response (which is often the case), the greater the concentration achieved, the greater the magnitude of response.