ABSTRACT
Benign fat neoplasms comprise more than half of all benign soft tissue tumors. They outnumber their malignant counterparts (liposarcomas) by a margin of over 100:1. They show various degrees of fatty differentiation manifested by adipocytes with vacuolated clear cytoplasm that bulge against or distort its nucleus. Caution should be rendered in differentiating some simulators of adipocytes including vacuolated histiocytes, metastatic signet ring carcinoma cells, clear cell melanoma, and mesenchymal cells producing cytoplasmic acid mucopolysaccharide.
