ABSTRACT
The need for nanosuspensions as a dosage form was recognized as a means to administer therapeutic quantities of water-insoluble dosage forms. Taxol nanosuspensions were prepared by emulsion templating, that is dissolving drug into a volatile solvent, homogenizing in an aqueous solution containing suitable stabilizers, and evaporating solvent to recover nanosuspensions. Crystal defects are an important consideration both where nanosuspensions are manufactured by growth, for example, crystallization, as well as by attrition, by milling, or homogenization. Phospholipid-coated nanosuspensions of dantrolene and sodium dantrolene were studied for treatment of malignant hyperthermia. The pharmacokinetics of itraconazole nanosuspension has been studied clinically in allergenic hematopoietic stem cell transplant recipients over a 14-day intravenous course of treatment. Growth in the applications of nanosuspension technology has occurred in response to the voluminous number of water-insoluble drug candidates that have emerged from discovery programs.
