ABSTRACT
This chapter presents the novel aerosol flow reactor method for the synthesis of single- and multicomponent nanoparticles as well as nanostructured, micronsized particles. In the aerosol flow reactor method, the solution containing solute(s) is atomized to produce droplets that are transferred with the aid of a carrier gas to a heated flow reactor. The chapter discusses the formation of the polymeric nanoparticles from several solvents. It also discusses the preparation of the composite powders using l-leucine to increase the stability of powders. The incorporation of l-leucine modifies particle surface structure and changes, for instance, spherical particles to wrinkled ones depending on the l-leucine content. A drying particle expands while water molecules penetrate through the l-leucine film and after complete removal of water the film collapses to give wrinkled morphology. The chapter describes the control of the polymer Eudragit® L100 nanoparticle morphology when produced from different solvent media.
