Neurochemistry and Pharmacology of the Dopamine System in Mice Lacking Vesicular and Plasma Membrane Uptake Mechanisms

Dopamine (DA) plays an important modulatory role in fast glutamatergic and GABAergic neurotransmission and therefore is critically involved in numerous physiological functions (Carlsson, 1987; Greengard, 2001). Dopaminergic dysfunction is believed to be involved in several brain disorders, such as parkinsonism, depression, addiction, schizophrenia, attention deficit-hyperactivity disorder (ADHD) as well as Tourette’s syndrome.