ABSTRACT

Reviewing research on the molecular basis of oxygen homeostasis, this text describes the changes in intracellular signalling and gene expression that lead to physiological responses to hypoxia in unicellular, invertebrate, and mammalian species. It examines O2 sensing systems in bacteria and archaea and demonstrates interrelationships among cell pr

part |5 pages

Part One GENOMICS OF OXYGEN SENSING

chapter 3|18 pages

Regulation of HIF-1 by Oxygen

chapter 4|17 pages

Oxygen or Redox-Dependent Regulation

chapter 6|16 pages

Hypoxia-Inducible Factor-1

chapter 8|33 pages

Molecular Adaptation to Hypoxia

part |7 pages

Part II OXYGEN SENSING IN THE CAROTID BODY, AND OTHER CELLS, ORGANS, AND ORGANELLES